Which laboratory result indicates a possible adverse effect of NSAID therapy in a client with rheumatoid arthritis?

A positive fecal occult blood test is indicative of gastrointestinal bleeding, which can be an adverse effect of nonsteroidal anti-inflammatory drugs (NSAIDs) therapy. NSAIDs can irritate the gastrointestinal lining and may lead to ulcers or bleeding in sensitive individuals, particularly those who have underlying conditions like rheumatoid arthritis.

The presence of blood in the stool suggests that the NSAID might be causing damage to the gastrointestinal tract, resulting in bleeding. This finding is significant for clients on NSAIDs because it could lead to serious complications if not addressed promptly. Clinicians often monitor for gastrointestinal symptoms and may consider alternative pain management strategies if such an adverse reaction occurs.

While other laboratory results, such as increased white blood cell count, decreased hemoglobin levels, or elevated liver enzymes, can indicate various conditions or effects related to other medications or diseases, they do not specifically highlight the gastrointestinal risks associated with NSAIDs as clearly as a positive fecal occult blood test does. Thus, the positive fecal occult blood test stands out as a direct indicator of a potential adverse effect from NSAID use in this context.