Which symptom could indicate liver damage in a client receiving long-term NSAID therapy?

Jaundice is a key indicator of liver damage, particularly in patients undergoing long-term non-steroidal anti-inflammatory drug (NSAID) therapy. When the liver is compromised, it loses its ability to properly process bilirubin, a byproduct of the breakdown of red blood cells. This results in a buildup of bilirubin in the blood, causing a yellowing of the skin and eyes, characteristic of jaundice.

In the context of NSAID usage, prolonged exposure to these medications can lead to liver toxicity or dysfunction, making the identification of jaundice critical in monitoring for potential liver damage. Additionally, jaundice can be a sign of other liver-related issues, such as hepatitis or cirrhosis, further supporting its relevance as a significant symptom in this scenario. Understanding this connection is essential for recognizing complications that can arise from extended NSAID therapy and ensuring timely medical intervention.