Which vital sign change may indicate sepsis?

Hypotension is a key vital sign change that may indicate sepsis because it reflects the body's response to an infection that has progressed to the point of systemic inflammation and impaired circulation. In sepsis, the bacterial toxins and inflammatory mediators lead to widespread vasodilation and increased permeability of blood vessels. As a result, blood pressure can drop significantly, leading to inadequate perfusion of vital organs.

Monitoring blood pressure is crucial in identifying the early signs of sepsis. The presence of hypotension, especially when coupled with other indicators such as elevated heart rate or altered mental status, should prompt immediate assessment and intervention, as this can progress to septic shock if not addressed promptly. Early recognition and treatment are vital for improving outcomes in patients with sepsis.

Bradycardia, elevated blood glucose, and hypothermia can also be associated with sepsis in different contexts, but hypotension remains one of the hallmark signs directly linked to the severe physiological response and can indicate a critical level of distress in the patient’s condition.